Publications

Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF et al..  2021.  In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.. Nat Metab. 3(5):682-700.

Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA et al..  2016.  In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.. Mol Ther. 24(7):1247-57.

Tchang BG, Askin G, Sahagun A, Hwang J, Huang H, Curanaj FAMendelso, Seley JJ, Safford MM, Alonso LC, Aronne LJ et al..  2021.  The independent risk of obesity and diabetes and their interaction in COVID-19: A retrospective cohort study.. Obesity (Silver Spring).

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.  2015.  Insulin demand regulates β cell number via the unfolded protein response.. J Clin Invest. 125(10):3831-46.

Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocaña A, O'Doherty RM, Polotsky VY, O'Donnell CP.  2007.  Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity.. Am J Respir Crit Care Med. 175(8):851-7.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocaña A, Minoguchi K, O'Donnell CP.  2008.  Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.. J Physiol. 586(3):899-911.

Sharma RB, Darko C, Alonso LC.  2020.  Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells.. J Biol Chem. 295(41):14164-14177.

Kong Y, Sharma RB, Nwosu BU, Alonso LC.  2016.  Islet biology, the CDKN2A/B locus and type 2 diabetes risk.. Diabetologia. 59(8):1579-93.

Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CWee, Alonso LC, Myers MG, Jonas J-C, Poitout V, Kulkarni RN et al..  2014.  The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.. PLoS One. 9(2):e87941.

Sharma RB, Alonso LC.  2014.  Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. 14(6):492.

Sharma RB, Landa-Galván HV, Alonso LC.  2021.  Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells.. Diabetes. 70(11):2431-2443.

Kong Y, Hsieh C-H, Alonso LC.  2018.  : A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease.. Front Endocrinol (Lausanne). 9:405.

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, Garcia-Ocaña A.  2012.  Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.. Diabetes. 61(5):1143-52.

Alonso LC, Rosenfield RL.  2003.  Molecular genetic and endocrine mechanisms of hair growth.. Horm Res. 60(1):1-13.

Stamateris RE, Landa-Galván HV, Sharma RB, Darko C, Redmond D, Rane SG, Alonso LC.  2023.  Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.. J Clin Invest. 133(18)

Alonso LC, Rosenfield RL.  2002.  Oestrogens and puberty.. Best Pract Res Clin Endocrinol Metab. 16(1):13-30.

Kong Y, Ebrahimpour P, Liu Y, Yang C, Alonso LC.  2018.  Pancreatic Islet Embedding for Paraffin Sections.. J Vis Exp. (136)

Lundberg RL, Marino KR, Jasrotia A, Maranda LS, Barton BA, Alonso LC, Nwosu BUdoka.  2017.  Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission.. J Pediatr Endocrinol Metab. 30(8):823-830.

Lakshmipathi J, Alvarez-Perez JCarlos, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC et al..  2016.  PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.. Diabetes. 65(5):1283-96.

Shukla AP, Tchang BG, Lam T, Steller I, Touhamy S, Askin G, Curanaj FAMendelso, Seley JJ, Lorber D, Safford MM et al..  2021.  Preadmission predictors of severe COVID-19 in patients with diabetes mellitus.. J Diabetes Complications. 35(8):107967.

Marino KR, Lundberg RL, Jasrotia A, Maranda LS, Thompson MJ, Barton BA, Alonso LC, Nwosu BUdoka.  2017.  A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes.. PLoS One. 12(5):e0176860.

Flach RJRoth, Danai LV, DiStefano MT, Kelly M, Menendez LGarcia, Jurczyk A, Sharma RB, Jung DYoung, Kim JHun, Kim JK et al..  2016.  Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.. J Biol Chem. 291(31):16221-30.

Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP.  2012.  Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice.. Obesity (Silver Spring). 20(7):1403-12.

Kong Y, Sharma RB, Ly S, Stamateris RE, Jesdale WM, Alonso LC.  2018.  T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.. Diabetes. 67(5):872-884.

Alonso LC.  2019.  T2D Risk Genes: Exome Sequencing Goes Straight to the Source.. Cell Metab. 30(1):10-11.