Publications

Stamateris RE, Landa-Galván HV, Sharma RB, Darko C, Redmond D, Rane SG, Alonso LC.  2023.  Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.. J Clin Invest. 133(18)

Skovsø S, Panzhinskiy E, Kolic J, Cen HHoward, Dionne DA, Dai X-Q, Sharma RB, Elghazi L, Ellis CE, Faulkner K et al..  2022.  Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.. Nat Commun. 13(1):735.

Nwosu BUdoka, Parajuli S, Jasmin G, Fleshman J, Sharma RB, Alonso LC, Lee AF, Barton BA.  2022.  Ergocalciferol in New-onset Type 1 Diabetes: A Randomized Controlled Trial.. J Endocr Soc. 6(1):bvab179.

Snyder JT, Darko C, Sharma RB, Alonso LC.  2021.  Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells.. Front Endocrinol (Lausanne). 12:734079.

Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF et al..  2021.  In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.. Nat Metab. 3(5):682-700.

Sharma RB, Landa-Galván HV, Alonso LC.  2021.  Living Dangerously: Protective and Harmful ER Stress Responses in Pancreatic β-Cells.. Diabetes. 70(11):2431-2443.

Sharma RB, Darko C, Alonso LC.  2020.  Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells.. J Biol Chem. 295(41):14164-14177.

Sharma RB, Snyder JT, Alonso LC.  2019.  Atf6α impacts cell number by influencing survival, death and proliferation.. Mol Metab. 27S:S69-S80.

Sharma RB, Darko C, Zheng X, Gablaski B, Alonso LC.  2019.  DNA Damage Does Not Cause BrdU Labeling of Mouse or Human β-Cells.. Diabetes. 68(5):975-987.

Kong Y, Sharma RB, Ly S, Stamateris RE, Jesdale WM, Alonso LC.  2018.  T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.. Diabetes. 67(5):872-884.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NAbraham, O'Donnell CP et al..  2016.  Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.. Diabetes. 65(4):981-95.

Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA et al..  2016.  In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy.. Mol Ther. 24(7):1247-57.

Kong Y, Sharma RB, Nwosu BU, Alonso LC.  2016.  Islet biology, the CDKN2A/B locus and type 2 diabetes risk.. Diabetologia. 59(8):1579-93.

Flach RJRoth, Danai LV, DiStefano MT, Kelly M, Menendez LGarcia, Jurczyk A, Sharma RB, Jung DYoung, Kim JHun, Kim JK et al..  2016.  Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.. J Biol Chem. 291(31):16221-30.

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.  2015.  Insulin demand regulates β cell number via the unfolded protein response.. J Clin Invest. 125(10):3831-46.

Sharma RB, Alonso LC.  2014.  Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. 14(6):492.

Stamateris RE, Sharma RB, Hollern DA, Alonso LC.  2013.  Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.. Am J Physiol Endocrinol Metab. 305(1):E149-59.