Publications

Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.  2015.  Insulin demand regulates β cell number via the unfolded protein response.. J Clin Invest. 125(10):3831-46.

Sharma RB, Snyder JT, Alonso LC.  2019.  Atf6α impacts cell number by influencing survival, death and proliferation.. Mol Metab. 27S:S69-S80.

Sharma RB, Alonso LC.  2014.  Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well? Curr Diab Rep. 14(6):492.

Shukla AP, Tchang BG, Lam T, Steller I, Touhamy S, Askin G, Curanaj FAMendelso, Seley JJ, Lorber D, Safford MM et al..  2021.  Preadmission predictors of severe COVID-19 in patients with diabetes mellitus.. J Diabetes Complications. 35(8):107967.

Singamsetty S, Shah FAli, Guo L, Watanabe Y, McDonald S, Sharma R, Zhang Y, Alonso LC, O'Donnell CP, McVerry BJ.  2016.  Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice.. Appl Physiol Nutr Metab. 41(1):12-9.

Skovsø S, Panzhinskiy E, Kolic J, Cen HHoward, Dionne DA, Dai X-Q, Sharma RB, Elghazi L, Ellis CE, Faulkner K et al..  2022.  Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.. Nat Commun. 13(1):735.

Snyder JT, Darko C, Sharma RB, Alonso LC.  2021.  Endoplasmic Reticulum Stress Induced Proliferation Remains Intact in Aging Mouse β-Cells.. Front Endocrinol (Lausanne). 12:734079.

Song W-J, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BWT, Lim OC, Yang KS, Radovick S, Novaira HJ et al..  2014.  Glucagon regulates hepatic kisspeptin to impair insulin secretion.. Cell Metab. 19(4):667-81.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NAbraham, O'Donnell CP et al..  2016.  Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.. Diabetes. 65(4):981-95.

Stamateris RE, Sharma RB, Hollern DA, Alonso LC.  2013.  Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.. Am J Physiol Endocrinol Metab. 305(1):E149-59.

Stamateris RE, Landa-Galván HV, Sharma RB, Darko C, Redmond D, Rane SG, Alonso LC.  2023.  Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.. J Clin Invest. 133(18)

Tchang BG, Askin G, Sahagun A, Hwang J, Huang H, Curanaj FAMendelso, Seley JJ, Safford MM, Alonso LC, Aronne LJ et al..  2021.  The independent risk of obesity and diabetes and their interaction in COVID-19: A retrospective cohort study.. Obesity (Silver Spring).

Tchang BG, Morrison C, Kim JTae, Ahmed F, Chan KM, Alonso LC, Aronne LJ, Shukla AP.  2022.  Weight Loss Outcomes With Telemedicine During COVID-19.. Front Endocrinol (Lausanne). 13:793290.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC et al..  2011.  Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.. Diabetes. 60(10):2546-59.

Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocaña A, O'Donnell CP, McVerry BJ.  2013.  Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice.. PLoS One. 8(6):e67716.

Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocaña A, Alonso LC, O'Donnell CP, McVerry BJ.  2009.  Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.. Crit Care Med. 37(9):2596-603.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocaña A, Minoguchi K, O'Donnell CP.  2008.  Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.. J Physiol. 586(3):899-911.

Zeng X, Wang Y, Farias K, Rappa A, Darko C, Sauve A, Huang Q, Alonso LC, Yang Y.  2025.  NRH, a potent NAD+ enhancer, improves glucose homeostasis and lipid metabolism in diet-induced obese mice through an active adenosine kinase pathway.. Metabolism. 164:156110.