Publications

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC et al..  2011.  Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.. Diabetes. 60(10):2546-59.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM et al..  2012.  ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.. Diabetes. 61(8):2004-15.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC et al..  2011.  Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.. Diabetes. 60(2):525-36.

Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocaña A, O'Donnell CP, McVerry BJ.  2013.  Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice.. PLoS One. 8(6):e67716.

Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocaña A, Alonso LC.  2012.  Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18.. Diabetes. 61(3):632-41.

Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NAbraham, O'Donnell CP et al..  2016.  Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor.. Diabetes. 65(4):981-95.

Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A.  2007.  Glucose infusion in mice: a new model to induce beta-cell replication.. Diabetes. 56(7):1792-801.

Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocaña A, Alonso LC, O'Donnell CP, McVerry BJ.  2009.  Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness.. Crit Care Med. 37(9):2596-603.

Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL et al..  2019.  Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.. Sci Signal. 12(610)

Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocaña A, O'Doherty RM, Polotsky VY, O'Donnell CP.  2007.  Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity.. Am J Respir Crit Care Med. 175(8):851-7.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocaña A, Minoguchi K, O'Donnell CP.  2008.  Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.. J Physiol. 586(3):899-911.

Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, Garcia-Ocaña A.  2012.  Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.. Diabetes. 61(5):1143-52.

Lakshmipathi J, Alvarez-Perez JCarlos, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC et al..  2016.  PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.. Diabetes. 65(5):1283-96.

Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP.  2012.  Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice.. Obesity (Silver Spring). 20(7):1403-12.

Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocaña A et al..  2013.  Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia.. Eur J Appl Physiol. 113(2):467-78.